The growing burden of non-communicable diseases (NCDs) represents a significant threat to health, development and economic growth in the Eastern Mediterranean Region. Working with the Eastern Mediterranean Region Office (EMRO) of the World Health Organization, the O’Neill Institute is undertaking a project that will assist EMRO and its member states in the prevention and control of NCDs through effective legal and regulatory interventions. The project will identify and systematically categorize effective laws, regulations, interventions and good practices from across the global designed to prevent and control NCDs, focusing on nutrition and diet, physical activity and tobacco consumption. The project will use this analysis to provide guidance on which legal instruments could be introduced with best effect in the Eastern Mediterranean Region, taking into account the diversity of countries in the Region. A second phase of the project will focus on developing guidelines and tools to support implementation of national prevention initiatives, including capacity building through the creation of multidisciplinary teams of public health experts and legislators.