Professor Rotenberg co-founded the Electronic Privacy Information Center (EPIC), an independent public interest research organization in Washington, DC,  in 1994. He is coauthor (with Anita L. Allen) of Privacy Law and Society (West Academic 2016), editor of The AI Policy Sourcebook (EPIC 2020), The Privacy Law Sourcebook: United States Law, International Law and Recent Developments (EPIC 2020), coeditor of Privacy in the Modern Age: The Search for Solutions (The New Press 2015), Litigation Under the Federal Open Government Laws (EPIC 2010), and Privacy and Technology: The New Landscape (MIT Press 1998). He is on the editorial boards of several academic journals, including European Data Protection Law (Lexxion – Germany), Journal of National Security Law & Policy (Georgetown Law – US), the Journal of Cyber Affairs (Wiley – China), and Law360 – Cybersecurity and Privacy (LexisNexis – US). His articles and commentaries have appeared in the Economist, the Harvard Business Review, the Harvard International Review, the Harvard Journal of Law and Public Policy, the New York Times, the OECD Observer, the Stanford Technology Law Review, and Techonomy, among others.

Professor Rotenberg has testified before the US Congress on more than 60 occasions. He has also spoken before the European Parliament several times, at judicial conferences many times, and given invited lectures in more than 40 countries. Professor Rotenberg has authored more than 100 amicus briefs for cases raising novel privacy and civil liberties issues for federal and state courts, including thirty amicus briefs for the U.S. Supreme Court. Through EPIC he maintains an active litigation practice, focusing on Freedom of Information Act and the Administrative Procedures Act.

Professor Rotenberg has served on advisory panels for the American Bar Association Section on Criminal Justice, the American Association for the Advancement of Science (AAAS), the Institute of Medicine (IOM), the International Telecommunications Union (ITU), the Internet Corporation for Assigned Names and Numbers (ICANN), the International Working Group on Data Protection (IWGDP), the National Academies of Science (NAS), the Organization of American States (OAS), UNESCO, and the OECD. He is a former chair of the Public Interest Registry, which established and manages the .ORG domain. His current research studies are with the Aspen Institute (Algorithmic Transparency) and the OECD in Paris (the Digital Economy, AI Expert Group).

At Stanford Law School, Marc Rotenberg was Articles Editor of the Stanford Law Review, President of the Stanford Public Interest Law Foundation (SPILF), and research assistant for Judge A. Leon Higginbotham, Jr. After law school, he served as Counsel to Senator Patrick J. Leahy on the Senate Judiciary Committee, specializing in law and technology. Professor Rotenberg is a member of the District of Columbia and Massachusetts bar, and the Supreme Court, the D.C. Circuit, First Circuit, Second Circuit, Third Circuit, Fourth Circuit, Fifth Circuit, Sixth Circuit, Seventh Circuit, and Ninth Circuit Courts of Appeal.

Professor Rotenberg is a Fellow of the American Bar Foundation, a Member of the Council on Foreign Relations, and has received several awards and honors, including the World Technology Award in Law, the American Lawyer Award for Top Lawyers Under 45, the ABA Cyberlaw Excellence Award, the Norbert Weiner Award for Social and Professional Responsibility, and the Vicennial medal from Georgetown University for 20 years of distinguished service.